Co-authors disclosed support from Dell Loy Hansen Heart Foundation Heart Institute, Intermountain Research and Medical Foundation, AstraZeneca, PCORnet, GlaxoSmithKline, CareCentra, and LabMe.ai, as well as licensing of intellectual property from Alluceo and CareCentra. Case Rep Infect Dis. and transmitted securely. J Clin Transl Res. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. Data are presented as mean (95% confidence interval [CI]) from the linear mixed-effects model adjusted for vaccine manufacturer, sex, blood type, age, occupation, and BMI. A higher IL-6 level was associated with older age, mixed-manufacturer vaccinations, intervals of less than 40 days between two doses of vaccination, and medical staff. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). Hum Vaccin Immunother (2022) 18:2078634. doi:10.1080/21645515.2022.2078634, 9. However, some studies have people wondering if blood type affects coronavirus risk. Li G, Cappuccini F, Marchevsky NG, Aley PK, Aley R, Anslow R, et al. But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. Applies to sars-cov-2 (covid-19) mrna-1273 vaccine: intramuscular suspension. Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. Shes most passionate about hiking, traveling, mindfulness, cooking, and really, really good coffee. } Clinics (Sao Paulo). Therefore, we speculate that the concentration of neutralizing antibodies may be increased more rapidly after the third or fourth dose of booster. Bruising for no. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all
1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Nous, Yahoo, faisons partie de la famille de marques Yahoo. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. The .gov means its official. Factors that influence humoral and cellular immune responses were defined within 240 days in individuals vaccinated with an inactivated Chinese vaccine. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: That link was established pretty early on in the pandemic and scientists didn't let it go. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, et al. Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. Here is all the latest news about convicted killer, Alex Murdaugh. The participants in the study (mixed-manufacturer vaccination for the two doses) and control (same-manufacturer vaccination for both doses) groups remained in local community health centers for at least 30min after vaccination to monitor safety, and the occurrence of any adverse event during this observation period was recorded. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. We dont know about asymptomatic carriersthat is, Type O could still pass along the virus to other people unknowingly just as much as Type A could. If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. Common side effects included: tenderness at the injection site for 73% of participants pain upon and after vaccination for 60% of participants fatigue for 50% of the participants muscle pain. The multiple linear regression analysis revealed that participants aged >50 years had lower reactive IFN- levels and B-lymphocyte counts than those aged 1830 years (Tables36, Figures3AG; Tables S8S15) (B = 0.15, p = 0.03; B = 0.04, p = 0.036, respectively) (Tables3, 5; Figures3A, D). Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. Now, a "Covid arm" is different from a skin reaction that . Where are we now, in 2022, on blood type and Covid? Disclaimer. J Clin Epidemiol (2022) 144:16372. Most participants rapidly developed neutralizing antibodies after two doses of the Chinese COVID-19 inactivated vaccine administered 3 weeks apart. Vaccines are still important, as are smart choices to protect yourself from germs. Received: 25 November 2022; Accepted: 20 February 2023;Published: 03 March 2023. doi:10.1016/S0140-6736(22)00770-X, 26. This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. SARS-CoV-2 and adverse reactions to SARS-CoV-2 vaccinations show a tropism for neuronal structures and tissues. If youre type O, you naturally make antibodies against Type A and Type B, Dr. Udden says. Moderna says 9.7% of their participants felt fatigued and 4.5% got . Additional research and review papers have confirmed that we're in more or less the same place: It looks like there really is an association between Type A blood and susceptibility to Covid and Type O blood and less susceptibility. sharing sensitive information, make sure youre on a federal This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. The results showed that those with A blood types were significantly more likely to contract the coronavirus compared with other blood types. As with all vaccines, side effects may occur after getting the COVID-19 vaccine. Opens in a new tab or window, Share on Twitter. To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. Whether the immunogenic response observed in this study will translate to better efficacy and effectivenessa fact that should be considered in strategic decisions about vaccination programsis unknown. Side effects can be a powerful deterrent stopping people from getting vaccinated. 2023 Feb 25;28(1):102. doi: 10.1186/s40001-023-00992-0. Clinics. One study published by the CDC reports that from March 2020 to January 2021, patients with COVID-19 had nearly 16 times the risk for myocarditis compared with patients who did not have COVID-19. The observations made in the "Study of blood group analysis and its correlation with lymphopenia in Covid- 19 infected people" were carried during the first wave of cases for two months in a retrospective manner. In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. 2021;8(2021):3619131. doi:10.1155/2021/3619131 Front Public Health. Our product picks are editor-tested, expert-approved. The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). P=0.11), hospitalization (OR 0.89, 95% CI 0. . This study had limitations. People with blood type O may be less vulnerable to Covid-19 and have a reduced likelihood of getting severely ill, according to two studies published Wednesday. Epub 2021 May 25. Following vaccination, the participating medical staff of Henan Provincial Peoples Hospital and Zhengzhou Municipal Traditional Medicine Hospital, and workers of the Henan Electric Power Exploration Company in central China were followed up monthly for 8 months between June 19, 2021, and April 30, 2022. .css-13y9o4w{display:block;font-family:GraphikBold,GraphikBold-fallback,Helvetica,Arial,Sans-serif;font-weight:bold;margin-bottom:0;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-13y9o4w:hover{color:link-hover;}}@media(max-width: 48rem){.css-13y9o4w{font-size:1.05rem;line-height:1.2;margin-bottom:0.25rem;}}@media(min-width: 40.625rem){.css-13y9o4w{font-size:1.28598rem;line-height:1.2;}}@media(min-width: 48rem){.css-13y9o4w{font-size:1.39461rem;line-height:1.2;margin-bottom:0.5rem;}}@media(min-width: 64rem){.css-13y9o4w{font-size:1.23488rem;line-height:1.3;}}This Coffee Shop Provides Free Therapy for Men, How To Stop Poop From Burning After Spicy Food, What to Do When You Hit Your Head Really Hard, 4 Things Every Man Should Know About Testosterone, The Truth About Testosterone and Your Libido, 20 Minutes of Exercise Lowers Hospitalization Risk. Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects: Impact of booster dose and breakthrough infections. Interestingly, the concentration of neutralizing antibodies decreased by an average of 0.004 IU (95% confidence interval [CI]: 0.0020.005, p < 0.001) per day after vaccination (Table2). Therefore, we designed a multicenter, longitudinal, observational study to evaluate the immunogenicity and reactogenicity of a second dose of inactivated vaccine among those who received the two vaccines from different manufacturers. Other neurological side effects occur in a much lower frequency. COVID vaccines and safety: what the research says. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. Research in other countries has shown that the antibody titer of individuals vaccinated with a different type of vaccine 28 days after the first vaccination was higher than that of individuals vaccinated with a vaccine from the same manufacturer for both doses, without an increase in adverse reactions (14). Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. Wong LP, Alias H, Siaw YL, Muslimin M, Lai LL, Lin Y, et al. Lower antibody concentrations were correlated with older age, longer duration after vaccination, non-health care workers, mixed-manufacturer vaccinations, and intervals of less than 40 days between two doses of vaccination, whereas lower IFN- levels and B-lymphocyte counts were associated with older age, blood type A, and non-health care workers. Many COVID-19 . Feelings of having a fast-beating, fluttering or pounding heartbeat COVID can cause heart problems, too Having COVID-19 can also cause heart problems. Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). YL, SW, and WY were involved in the project management and organizational work. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). The levels of neutralizing antibodies and IFN- were higher in medical staff 240 days after vaccination than in workers. Associations between blood type and COVID-19 infection, intubation, and death. And for more regular updates on the virus, sign up for our daily newsletter. CNN . There were no changes in IFN- levels and CD4 T+ lymphocyte count on days 1 to 240 (B = 0.2, 95% CI 0.03 to 0.4, p = 0.09 and B = 0.004, 95% CI 0.005 to 0.003, p = 0.105; Tables3, 4) in participants stimulated with the SARS-CoV-2 S antigen. This can progress to affect the rest of the body and cause. -, Finsterer J, Scorza FA, Scorca CA. government site. No use, distribution or reproduction is permitted which does not comply with these terms. Association between mRNA vaccination and COVID-19 hospitalization and disease severity. Table5 Factors associated with B-lymphocyte count after the administration of the inactivated Chinese COVID-19 vaccine. Those four main blood groupsA, AB, B, and Ocan be Rh-positive or Rh-negative, meaning that there are 8 blood groups in total. doi:10.1002/jmv.27825, 10. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. These include anaphylaxis, a severe reaction . On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. All authors contributed to the article and approved the submitted version. You've read a lot about what puts you at an increased risk of having a severe case of COVID-19, from smoking to carrying around extra weight to being over a certain age. Opens in a new tab or window. doi:10.1016/S1473-3099(21)00479-5, 17. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19,. Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. What Your Blood Type Has to Do With Getting Covid, This Coffee Shop Provides Free Therapy for Men, Your Privacy Choices: Opt Out of Sale/Targeted Ads. Based on the duration after vaccination of the participants, we divided the duration after vaccination of the participants into eight groups: 114, 1530, 3060, 6190, 91120, 121150,151180, and 181240 days. The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, et al. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. These include soreness where the jab was. Gao GF. Furthermore, based on the study of Lusting etal. These quick trivia tidbits will help you kill your boredom and impress your friends. The side effects mean your body is working hard to build the antibodies and cells it will need to fight the virus, if or when you are exposed to it. U.S. federal health agencies have recommended pausing the use of Johnson & Johnson's COVID-19 vaccine after six recipients developed a rare disorder involving blood clots, in a fresh setback to . Would you like email updates of new search results? In the future, we will include more participants after administering booster vaccines and conduct pseudo-virus neutralization tests to address these limitations. Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. Based on their age, we divided the participants into three groups, namely, 1830, 3150, and >50 years old. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). Reactogenicity analysis was based on solicited adverse events in 425 and 143 participants from the control and intervention groups, respectively, 30 days after vaccination. There were no differences in the positive rate of neutralizing antibodies between the groups throughout the observation period (p = 0.891; Figure2A). Blood type doesnt affect much in our daily lives. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. J Neuroimmunol. Discussion: Two doses of the Chinese inactivated vaccine induced robust and rapid antibody expression and cellular immune responses. Additionally, "Rh had a lower [adjusted relative risk] of severe COVID-19 illness or death.". In all cases, the immune system creates antibodies that activate platelets in the bloodstream, he said. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. Jiangsu Provincial Center for Disease Control And Prevention, China. In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Blood type is actually a pretty weak player, Dr. Udden says. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. -, Finsterer J, Scorza FA. But let's back up first. Opens in a new tab or window, Visit us on LinkedIn. "Up to 10 percent of people who have COVID experience side effects such as . 2021 Oct 11;76:e3286. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Hum Vaccin Immunother. These include: chills fatigue fever headache muscle pain nausea pain at the injection site redness at the. Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: A randomised, open-label, single-centre trial. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. Participants with documented reverse transcription-polymerase chain reaction-confirmed COVID-19 or those who had been vaccinated with any other vaccine (e.g., influenza or others) or booster vaccine since the primary dose were excluded. This unusual clotting may cause different complications, including organ damage, heart attack and stroke. The relationships between blood type-, age-, sex-, and occupation-related reactivities of neutralizing antibodies and cellular immune responses were demonstrated. 2021 John Wiley & Sons A/S. "There are two possibilities: You're Type O so you might not contract the virus because it has no landing stripthere's nothing to attach to," Dr. Udden explains. We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Because each set underwent nine comparisons, significance for individual comparisons was set at P=0.006, meaning none of these associations were significant, they wrote in JAMA Network Open. This can result in pain, redness, or swelling at . These Type A antibodies might make it more difficult for SARS-CoV-2 to attach to its receptor in Type O blood and multiply in the body, he explains. 30. Patients were identified based on self-report of receiving the vaccine. Just because youre Type O doesnt mean youre in the clear. Unable to load your collection due to an error, Unable to load your delegates due to an error. Guillain-Barre syndrome should be monitored upon mass vaccination against SARS-CoV-2. COVID-19 vaccine coverage, concerns, and preferences among Chinese ICU clinicians: A nationwide online survey. Progress and challenge of COVID-19 vaccine development. National Library of Medicine Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. Amyloid -related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report. doi:10.1016/S1473-3099(21)00680-0, 27. Lancet Respir Med (2021) 9:9991009. Please enable it to take advantage of the complete set of features! doi: 10.6061/clinics/2021/e3286. J Neuroimmunol. Share on Facebook. Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. Previous research has found that people with A blood types are more at risk. (D) Kinetics of B-lymphocyte count according to age. Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, et al. They noted conflicting research about blood types and COVID, with studies around the world finding links between the two -- particularly, increased susceptibility in people with type A and/or decreased risk with type O -- while others found no links. eCollection 2021. 2022 Dec 22;78:100157. doi: 10.1016/j.clinsp.2022.100157. The signs are trouble breathing, swelling of the face and throat, rash, and low blood pressure. Online ahead of print. We may earn commission from links on this page, but we only recommend products we back. "Given the large and prospective nature of our study and its strongly null results, we believe that important associations of SARS-CoV-2 and COVID-19 with ABO groups are unlikely and will not be useful factors associated with disease susceptibility or severity on either an individual or population level for similar environments and ancestries," they concluded. why people on blood thinners shouldn't get the vaccine. This can begin anywhere from a few minutes to a few hours after the injection. 2021;76:e3286. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. If You Have One of These Blood Types, You May Be Safe From COVID, It Only Takes This Long to Get COVID in a Room With Someone Who Has It, These 2 Places Could Be Closing Soon, White House Official Warns, How Likely You Are to Catch COVID in the Next Month, Expert Says, If You Have This Symptom, There's an 80 Percent Chance You Have COVID, tracked the blood types of nearly 2,200 COVID-19 patients, A blood types were significantly more likely. Molly Walker is deputy managing editor and covers infectious diseases for MedPage Today. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. In conclusion, this study is the first to evaluate robust humoral and cellular immune responses at 240 days in 595 participants after a second dose of inactivated vaccine in individuals primed with the first dose. The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. It may affect your immune systems strength or your inflammatory response to the infection. A new large-scale study published in the journal Annals of Internal Medicinefound that your risk of catching COVID-19 is slashed if you have a particular blood type. We are committed to bringing you researched, expert-driven content to help you make more informed decisions If a patient was O-negative, they were particularly protected from the novel coronavirus, the authors noted. Bookshelf "Or by being Type O, the virus gets in but the A antibody prevents it from docking with enough cells to cause disease. Vaccination is the most effective measure to reduce mortality from COVID-19 and serious diseases (12); however, vaccines are scarce in certain countries and some regions in China (13). The question of a possible relationship between blood type and disease risk has been a topic of active research since early in the pandemic. In cases of severe adverse events, the investigator contacted the participant, and the intensity of adverse events was graded according to the adverse events severity scale as follows: 1, mild; 2, moderate; 3, severe; or 4, life-threatening. 2022 Galvanized Media. We excluded 14 (2.4%) participants from the regression analysis and mixed model analysis due to missing data: 8 who withdrew their consent, 2 who did not answer age-related questions, 2 who missed a follow-up visit, and 2 who did not provide blood samples (Figure1). Bestlifeonline.com is part of the Meredith Health Group. doi: 10.1016/S2213-2600(21)00220-4, 19. Side effects after getting a #COVID19 vaccine are normal signs your body is building protection. Safety of COVID-19 Vaccines Some people have no side effects. Acta Neurol Scand. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion There's no need to worry about any of the flu-like symptoms. Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. xhr.open('POST', 'https://www.google-analytics.com/collect', true); Associations were observed between blood type and production of neutralizing antibodies and IFN-. In China, the latter three have been approved and are produced by eight manufacturers. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses.
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