This means it works against many different types of bacteria. 2 Repeat WebDiverticulitis is evaluated with CT of the abdomen and pelvis with water-soluble contrast given orally and rectally; IV contrast also is given when not contraindicated. Treatment of overdose will depend on the symptoms you have. sharing sensitive information, make sure youre on a federal Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). Reconstituted Augmentin suspensions should be stored in a refrigerator and discarded after 10 days. [Current treatment of bacterial vaginosis]. In addition to those side effects, children can experience tooth discoloration. Cellulitis is a type of skin infection. Amoxicillin Dosage Medically reviewed by Drugs.com. When the patient has left lower quadrant tenderness and a CRP level greater than 50 mg per L (476.20 nmol per L) in the absence of vomiting, the likelihood of acute (Resistant bacteria dont respond to treatment with a certain antibiotic.). Vaginal yeast infections can sometimes occur after treatment with antibiotics, including Augmentin. Participants all received either metronidazole-with 8600 Rockville Pike doi: 10.1002/14651858.CD009277.pub2. Augmentin contains two drugs: amoxicillin and clavulanic acid. Augmentin is a combination medication that contains amoxicillin in addition to another drug. This combination makes Augmentin work against more types of bacteria than antibiotics that contain amoxicillin alone. Ultrasonography was found to have a specificity of 99.8 percent in one large retrospective study.16. If this septic process erodes into adjacent structures, it may result in fistula formation. Patient information: See related handout on diverticular disease, written by the authors of this article. WebTreatment consisted of oral antibiotics for 7 days (amoxicillin-clavulanic or ciprofloxacin plus metronidazole in patients with penicillin allergy). Disagreements were resolved by discussion or involvement of the third author. Its used to treat infections caused by bacteria. However, you may not notice improvement in your symptoms for a few days. Rashes that develop several days after you take the medication and appear as flat, red patches often indicate a different kind of rash thats not caused by an allergic reaction. You should take Augmentin XR at the start of a meal. The half-life of the amoxicillin component is about 1 hour and 20 minutes, and about 1 hour for clavulanic acid. Patients hospitalized with acute diverticulitis should receive metronidazole or clindamycin (Cleocin) combined with an aminoglycoside, a monobactam, or a third-generation cephalosporin. More trials are needed to obtain more precise effect estimates. CT-guided percutaneous drainage may be appropriate for small abscesses or while patients with sepsis are being stabilized for surgery.3,6. Symptoms of an overdose of Augmentin can include: If you think you or your child has taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. Generic drugs are often less expensive than the brand-name version. However, an FDA study showed that many medications may still be good beyond the expiration date listed on the bottle. It is intended to aid selection of an appropriate antibiotic for typical patients with infections commonly seen in general practice. Because of the theoretic potential to exacerbate perforation, endoscopic examination is acutely contraindicated unless inflammatory bowel disease, ischemic colitis, or carcinoma is highly suspected.17 Colonoscopy always should be performed six to eight weeks after recovery from acute diverticulitis to exclude coexisting neoplastic disease. Copyright 2023 American Academy of Family Physicians. Epub 2019 Jan 25. Cochrane Database Syst Rev. This can cause dangerous side effects. Augmentin is not FDA-approved for treating strep throat, which is also known as streptococcus pharyngitis. Authors of trials were contacted to obtain additional data if needed or for preliminary results of ongoing trials. In addition, the Infectious Diseases Society of America does not recommend Augmentin for treating most cases of strep throat. amebicides, miscellaneous antibiotics, For consumers: official website and that any information you provide is encrypted Has a high potential for abuse. Augmentin is FDA-approved to treat ear infections, also known as otitis media, in children and adults. Learn about the possible side effects of taking amoxicillin. If you experience them, it doesnt mean you have an allergy to the medication. If this occurs, contact your doctor. This class of antibiotics causes skin rash more often than most other kinds of antibiotics. Each diverticulum is typically 5 to 10 mm in diameter, but at times they can exceed 20 mm. Antibiotics to prevent complications following tooth extractions. The generic version of this drug is available in the same forms as Augmentin, as well as in a chewable tablet. Before Treatment is typically antibiotics for seven to 10 days. This date is typically one year from the date the medication was dispensed. Accessibility Sulfatrim Pediatric The following information is provided for clinicians and other healthcare professionals. Intestinal obstruction is uncommon in diverticulitis, occurring in approximately 2 percent of patients. The https:// ensures that you are connecting to the HHS Vulnerability Disclosure, Help The form approved for animals is called Clavamox. Tylenol (acetaminophen) or a heating pad for abdominal pain. Immature band forms may be present. Augmentin is commonly used in adults and children to treat infections of the urinary tract, respiratory tract, ear, sinuses, and skin. After a second episode, the probability of a third episode surpasses 50 percent, and subsequent attacks are less likely to respond to medical therapy and also have a higher mortality rate.19 Surgical referral should be considered for patients with recurrent episodes or aggressive disease at a young age. Computed tomography is recommended for diagnosis when inflammation is present. The suspension comes in different concentrations. But if your body is fighting an infection, youre more likely to feel weak or tired. Because of this, NSAIDs and glucocorticoids should be used with caution in patients who have known diverticular disease. The white blood cell count usually is elevated with a predominance of polymorphonuclear cells. Some may be better suited for you than others. E. coli . Method: Augmentin is approved to treat certain types of respiratory infections. Diverticular colitis. 2020 Oct;57(10):100862. doi: 10.1016/j.cpsurg.2020.100862. Reproduction in whole or in part without permission is prohibited. An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. There's a consensus that antibiotics should be reserved for patients who really need them, and their routine use in uncomplicated diverticulitis is no longer recommended. The arrowhead sign consists of focal thickening of the colonic wall with an arrowhead-shaped lumen pointing to the inflamed diverticula ( Figure 2Figure 2).14 In one large prospective study,15 investigators demonstrated the ability of CT to accurately predict medical treatment failure or risk of complications by determining the presence of severe disease (abscess or extraluminal air or contrast). Cipro XR, For professionals: Similarly, no evidence supports the use of antispasmodic agents, despite the cramping and bloating often associated with symptomatic diverticular disease.3, Classically, diverticulitis is characterized by acute, constant abdominal pain most often occurring in the left lower quadrant. Can poor sleep impact your weight loss goals? Diverticulitis is inflammation of an abnormal pouch (diverticulum) in the intestinal wall, usually found in the large intestine (colon). By following a liquid diet as much as possible, with the occasional boiled or roasted vegetable and raw whole foods such as WebAmoxicillin-clavulanate is the generic version of Augmentin XR. Augmentin can be crushed. Has a potential for abuse less than those in schedules 1 and 2. Surprisingly, misinterpretation of the influence of hypoalbuminemia on pharmacokinetics and the clinical effects of drugs seems to be a current problem, even though hypoalbuminemia has no impact on the pharmacologically active exposure. A systematic review and meta-analysis. Cochrane Database Syst Rev. 2019 Feb;23(2):87-100. doi: 10.1007/s10151-018-1919-6. Acute diverticulitis is a common manifestation of diverticular disease. For the outcome of short-term complications there may be little or no difference between antibiotics and no antibiotics (RR 0.89; 95% CI 0.30 to 2.62; 3 studies, 1329 participants; low-certainty evidence). Traditionally, diverticula are identified by barium enema, and additional investigations are performed as indicated to rule out other potential causes of symptoms in individual patients. the type and severity of the condition youre using Augmentin to treat, immediate-release tablet: 250 mg/125 mg, 500 mg/125 mg, 875 mg/125 mg, extended-release tablet: 1,000 mg/62.5 mg, liquid suspension: 125 mg/31.25 mg per 5 mL, 250 mg/62.5 mg per 5 mL, vaginitis (caused by problems such as yeast infection), yellowing of your skin or the whites of your eyes, trimethoprim-sulfamethoxazole (Bactrim, Sulfatrim), doxycycline (Acticlate, Doryx, Doryx MPC, Vibramycin), doxycycline (Acticlate, Doryx, Doryx MPC). However, animal studies dont always predict the way humans would respond. Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. Rankings. Augmentin is considered a first-choice medication for this condition. These patients should be placed on bowel rest and treated with intravenous fluids and intravenous antibiotics ( Table 3Table 36). It's not clear yet if we can prevent diverticulosis or diverticulitis. Cardiovascular health: Insomnia linked to greater risk of heart attack. Amoxicillin-clavulanate (875mg/125mg) PO BID or amoxicillin-clavulanate extended release (1,000mg/62.5mg) PO BID or Moxifloxacin 400mg PO daily Duration of However, if its just a few hours until your next dose, skip the missed dose and take the next one on schedule. Levsin, In patients with uncomplicated diverticulitis who are clinically stable and able to tolerate fluids, outpatient treatment with broad-spectrum antibiotics covering anaerobes and gram-negative rods is appropriate ( Table 3Table 36). Abscess: An abscess is a pocket of pus in the body caused by a bacterial infection. However, research on this interaction is inconsistent and controversial. Augmentin should only be used during pregnancy if theres a clear need for its use. The .gov means its official. Historically, physicians have recommended avoiding ingestion of seeds, corn, popcorn, and nuts for fear that they might become entrapped in diverticula, but no controlled studies support this dietary restriction. Common choices are metronidazole (Flagyl) plus a quinolone; metronidazole plus trimethoprim-sulfamethoxazole (Bactrim, Septra); or amoxicillinclavulanic acid (Augmentin). They may also check your oxygen levels. Conclusion: The overall quality of evidence for outcomes was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Spread out the doses so that theyre about 12 hours apart. Taking it with a meal may reduce stomach upset and help your body absorb the drug better. Only two (3%) required admission because of persisting abdominal pain and vomiting, respectively. This site needs JavaScript to work properly. 2017 Nov 25;11(11):CD009277. Antibiotic treatment should be continued for seven to 10 days. Amoxicillinclavulanic acid (Augmentin) is effective against both types of bacteria. Hyosyne, Augmentin pills should be stored at room temperature in a tightly sealed and light-resistant container. Below is a list of medications that can interact with Augmentin. WebAmoxicillin with gentamicin and metronidazole Amoxicillin: 500 mg three times a day (increased to 1 g four times a day if severe infection) Gentamicin: Initially 5 to 7 mg/kg eCollection 2022 Jul. Show filters 1 2 Next View all results on one These include bacteria that cause: Augmentin comes in three forms, all of which are taken by mouth: Augmentin is available in a generic form. Some antibiotics, including Augmentin, might decrease how well oral contraceptives (such as the birth control pill) work. Uncomplicated diverticulitis has traditionally been treated with antibiotics, as diverticulitis has been regarded as an infectious disease. Three studies compared no antibiotics to antibiotics; all three were original RCTs of which two also published long-term follow-up information. MRI is an alternative for pregnant and young patients ( 1 , 2 ). This could result in increased bleeding. Augmentin is considered a broad-spectrum antibiotic. 2017 Feb 22;2(2):CD012131. Metronidazole If you take an anticoagulant drug with Augmentin, your doctor may need to monitor your bleeding risk more often. The general and surgical management of these infections are discussed in detail elsewhere. For instance, some can interfere with how well a drug works, while others can cause increased side effects. Peridiverticular abscesses can progress to form fistulas between the colon and surrounding structures in up to 10 percent of patients. Augmentin tablets or powder and Augmentin XR should be stored in the original container at temperatures of 77 degrees F (25 degrees C) or less. Several surgical options are available, including resection with primary anastomosis, resection with colostomy and closure of the rectal stump, transverse colostomy and drainage, and laparoscopic colectomy. sharing sensitive information, make sure youre on a federal Amoxicillin is one of the most commonly prescribed antibiotics and is used to treat everything from bronchitis to pneumonia to ear infections, tonsillitis, and more. 2022 Aug 18;81:104431. doi: 10.1016/j.amsu.2022.104431. PMC Typical findings include spiculation of the mucosa, spasm, abscess, or evidence of frank perforation. Epub 2020 Jul 18. WebDiverticulitis. Applicability, safety and efficiency of outpatient treatment in uncomplicated diverticulitis. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Published by John Wiley & Sons, Ltd. If barium enema is performed, water-soluble contrast should be used. Sharing this information can help you avoid potential interactions. The decision about which option to choose is best guided by an experienced surgeon and the patients preference. This can include abscesses, bleeding, bowel obstructions, fistulas, bowel perforation, or needing bowel surgery, as follows: 2. Careers. doi: 10.1002/14651858.CD012131.pub2. Would you like email updates of new search results? However, its used off-label to treat it. 2012 Nov 14;11:CD009092. WebYes, diverticulitis patients should take probiotics. If right upper quadrant pain or elevated transaminase levels occur, evidence of a pyogenic liver abscess should be sought. If you take it twice daily, spread out the doses so that theyre roughly 12 hours apart. An analysis of two separate cohorts of adults who received antibiotics for diverticulitis indicates that amoxicillin-clavulanate is a safe and effective treatment and may reduce the risk of fluoroquinolone-related harms, US researchers reported today in the Annals of Internal Medicine. [Acute diverticulitis can be treated without antibiotics] Abstract Diverticulitis is a complication to the common condition diverticulosis. Uncomplicated diverticulitis has traditionally been treated with antibiotics. Risk factors for diverticulitis, however, may suggest, that the condition is inflammatory rather than infectious. Augmentin is excreted in breast milk in small amounts. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. This increases the amount of medication your body absorbs and helps reduce stomach upset. 1 Most are for acute respiratory infections, and in quantities several-fold more than recommended by Australian guidelines. See permissionsforcopyrightquestions and/or permission requests. The diagnosis and treatment of lower GI bleeds require a coordinated approach. Bethesda, MD 20894, Web Policies If you have trouble swallowing pills, ask your doctor or pharmacist about taking Augmentin liquid suspension instead. 2019 Aug;34(8):1413-1420. doi: 10.1007/s00384-019-03343-w. Epub 2019 Jul 2. There is no known interaction between Augmentin and Tylenol (acetaminophen). Patients often note that attacks are precipitated by eating. Patients with suspected diverticulitis should undergo computed tomography with intravenous and oral contrast rather than other diagnostic modalities such as endoscopy or contrast radiography. For patients receiving antibiotics for outpatient diverticulitis, amoxicillinclavulanate seems preferable to metronidazole plus a fluoroquinolone, according to an observational study in the Annals of Internal Medicine. Although the pathogenic mechanisms of diverticular disease are poorly understood, they are clearly related to complex interactions of colon structure, intestinal motility, diet, and genetic features.4. Augmentin and Augmentin XR are FDA-approved for treating pneumonia. Copyright 2005 by the American Academy of Family Physicians. This antibiotic can cause such side effects as headaches, rashes, nausea and vomiting and restlessness. Activity is based on recent site visitor activity relative to other medications in the list. Clavulanic acid is also a beta-lactam that can inactivate some forms of beta-lactamase. Int J Colorectal Dis. These usually go away on their own after a few days. It has a currently accepted medical use in treatment in the United States. Curr Probl Surg. If either type of tablet is scored (has an indented line across it), it can be split in half. It takes a few days: You don't say how long since you started the antibiotics. It takes a few days for diverticulitis and similar infections to improve with antibioti It takes a few days for diverticulitis and similar infections to improve with antibioti Best food forward: Are algae the future of sustainable nutrition? Hematochezia is rare and should suggest other diagnoses.3. Colovesical fistulas are the most common variety and require surgery for treatment. AHFS DI Monograph, Brand names: Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. Antibiotics are sometimes used for treating certain types of acne. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Some researchers have proposed that more painful disease is associated with an increased motility index and increased intraluminal pressure.8 Prospective studies9,10 in men have shown no connection between symptomatic diverticular disease and smoking, caffeine, or alcohol intake, although lack of physical activity appears to play at least an indirect role. Abraha I, Binda GA, Montedori A, Arezzo A, Cirocchi R. Cochrane Database Syst Rev. The clavulanic acid ingredient makes Augmentin effective against bacteria that amoxicillin or other penicillin drugs may not work against when theyre taken by themselves. Three fourths of the remaining 15 to 20 percent of patients have symptomatic diverticular disease with colicky abdominal pain but no inflammation. WebDiverticulitis. Take Augmentin exactly according to your doctors instructions. The following list contains some of the key side effects that may occur while taking Augmentin. Diverticulosis is a common disease among Western and developed nations. The dosage depends on the condition being treated, its severity, and the age or weight of the child. If you miss a dose, take it as soon as you can. In patients with uncomplicated diverticulitis, opt for oral cephalosporin plus metronidazole over antibiotics given using amoxicillin orclavulanic acid. WebAcute diverticulitis is defined as inflammation, generally considered to be due to microperforation of a diverticulum. Nevertheless, a high-fiber diet, fiber supplementation, or both generally are recommended and are likely to do no harm. You can take Augmentin on an empty stomach or with a meal. Cleocin HCl, Augmentin starts working within a few hours of when you take it. Kim JY, Park SG, Kang HJ, Lim YA, Pak KH, Yoo T, Cho WT, Shin DW, Kim JW. For unknown reasons, only a small percentage of patients with diverticulosis develop symptomatic diverticular disease. Background: The site is secure. The rate of emergency surgery within 30 days may be lower with no antibiotics compared to antibiotics (RR 0.47; 95% CI 0.13, 1.71; 1329 participants; 3 studies; low-certainty evidence). In severe cases, surgery may be required to remove the affected portion of the intestine. Diverticula are small, bulging pouches A high-fiber diet may also be recommended to help prevent future diverticulitis flare-ups. Investigation of the clinical features and recurrence patterns of acute right-sided colonic diverticulitis: A retrospective cohort study. Taking Augmentin with oral anticoagulant drugs such as warfarin (Coumadin, Jantoven) might increase the effects of the anticoagulants. Objectives: 2022 Oct 15. doi: 10.1007/s00432-022-04405-3. Exceptions to this fact are highly protein-bound anaesthetics with high elimination Abuse may lead to severe psychological or physical dependence. Probiotics are live beneficial bacteria that balance out the unhealthy bacteria found in the gut. The ratio of drug to drug is different for each strength, so one strength cant be substituted for another. Brand names: Bronchitis is often caused by a virus, so antibiotics are not usually effective in treating it. A tender mass may be palpable on physical examination. Laboratory studies and imaging can be used judiciously to confirm a diagnosis of diverticulitis and to exclude other potential causes of similar symptoms ( Table 2Table 2). Before taking Augmentin, talk with your doctor about any medical conditions you have. Serious side effects and their symptoms can include the following: Many medications, including Augmentin, can cause rash in some people. Klebsiella . Symax SR Augmentin XR is usually considered a second-choice antibiotic for diverticulitis. Bookshelf Has a low potential for abuse relative to those in schedule 3. Diverticular disease includes a spectrum of conditions sharing the underlying pathology of acquired diverticula of the colon. Antibiotic therapy aimed at anaerobes and gram-negative rods is first-line Raised, itchy, white, or red bumps that occur after the first couple doses of Augmentin may indicate an allergy to the medication. By Sarah Bence. The generic name of Augmentin is amoxicillin/clavulanate potassium. It should be used when other medications such as trimethoprim-sulfamethoxazole cannot be used. If theyre more severe or dont go away, talk to your doctor or pharmacist. Multiple attacks can lead to progressive fibrosis and stricture of the colonic wall. WebOtitis media- 75 - 100 mg/kg/day given in 4 divided doses for 5 - 10 days (PI) Strep throat- 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (IDSA) Urinary tract infection- 50 - 100 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 7 - 14 days (CTE) Adults (15 years and older) Clipboard, Search History, and several other advanced features are temporarily unavailable. Only three RCTs on the need for antibiotics are currently available. Amoxicillin is a beta-lactam antibiotic that has bactericidal activity against Gram-negative and Gram-positive bacteria. The other ingredient, which is called clavulanic acid, helps the amoxicillin in Augmentin work against bacteria that are normally resistant to amoxicillin when its used alone. According to the Infectious Diseases Society of America, Augmentin is not a first-choice antibiotic for UTI. Augmentin and amoxicillin are often used to treat similar types of infections. Complications of diverticulitis include abscess, fistula, bowel obstruction, and free perforation. Diverticulitis: An Update From the Age Old Paradigm. showall, Drug class: Augmentin is FDA-approved for treating UTI. Ciprofloxacin stops the multiplication of bacteria by its inhibition and reproduction of the bacterias DNA 1. 2022 Jul 22;14(7):e27159. What is the difference between Augmentin and amoxicillin? WebSerious infections or respiratory infections: The typical dose is to take 875 mg of amoxicillin by mouth every 12 hours, or to take 500 mg of amoxicillin by mouth every 8 hours. government site. Typical dosage: 45 mg/kg/day (based on the amoxicillin component of Augmentin), using the 200-mg/5-mL or 400-mg/5-mL suspension. Consensus guidelines6 recommend a high-fiber diet in these patients to prevent symptomatic diverticular disease, although there are no randomized controlled trials to support or refute this strategy. Using medical claims data from 2000 to 2018, researchers identified nearly 120,000 adults aged 18 to 64 who For more information on the possible side effects of Augmentin, or for tips on how to deal with a troubling side effect, talk with your doctor or pharmacist. In some cases, they may administer intravenous (IV) fluids. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Click here to learn more. Adult dose of amoxicillin Commonly, amoxicillin is used as a 500 mg oral or intravenous drug. Flagyl has an average rating of 6.5 out of 10 from a total of 73 ratings for the treatment of Diverticulitis. 51% of reviewers reported a positive effect, while 19% reported a negative effect. 73 ratings from 80 user reviews. Compare all 20 medications used in the treatment of Diverticulitis. Please DO NOT take Flagyl. CT with intravenous and oral contrast is the test of choice to confirm a suspected diagnosis of diverticulitis.13 The finding of pericolic fat infiltration ( Figure 1Figure 1) is diagnostic.14 Other common findings include thickened fascia (78.9 percent), muscular hypertrophy (26.3 percent), and an arrowhead sign (23.7 percent). Please enable it to take advantage of the complete set of features! Antibiotics, in the case of infection WebInfo: for empiric tx in low-risk pts; give w/ ciprofloxacin; dose based on amoxicillin component; if 45 mg/kg/day regimen, use 200 mg/28.5 mg or 400 mg/57 mg forms; if 90 mg/kg/day regimen and wt 40 kg, use 600 mg/42.9 mg/5 mL susp avail. Fullness or tenderness in the left lower quadrant, or occasionally a tender palpable loop of sigmoid colon, often is appreciated on physical examination. An official website of the United States government. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. Is the ketogenic diet right for autoimmune conditions? Lodi G, Azzi L, Varoni EM, Pentenero M, Del Fabbro M, Carrassi A, Sardella A, Manfredi M. Cochrane Database Syst Rev. Careers. WebAlthough the absolute maximum Amoxicillin dose is 4000mg/day, we recommend the following for usual maximum dosing when targeting a high dose (80-90mg/kg/day): Amoxicillin suspension - usual maximum 2000mg/day = 1000mg/dose BID; Amoxicillin tablet - usual maximum 875mg/dose or 1000mg/dose (2 of the 500mg tablets) For this update, a comprehensive systematic literature search was conducted in Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, ClinicalTrials.gov and WHO International Clinical Trial Registry Platform on February 2021. Amoxicillin is a prescription drug for short-term treatment of certain bacterial infections. Perforation has been linked to nonsteroidal anti-inflammatory drug (NSAID) use in case-control studies.20 Glucocorticoids may increase this risk. Symax SL, Randomised controlled trials (RCTs), including all types of patients with a radiologically confirmed diagnosis of left-sided uncomplicated acute diverticulitis. You can Bactrim DS,